Retatrutide
Synthetic GIP / GLP-1 / glucagon receptor tri-agonist peptide
For research use only. Not for human consumption. This product is supplied strictly for in-vitro laboratory research and analytical use by qualified researchers aged 21+. It is not a drug, food, dietary supplement or cosmetic, and is not intended to diagnose, treat, cure or prevent any disease. No information on this site is medical advice or usage guidance.
About Retatrutide
Retatrutide (development code LY3437943) is a synthetic, 39-amino-acid peptide designed to engage three related class B G protein-coupled receptors: the GIP receptor, the GLP-1 receptor and the glucagon receptor.
Its sequence incorporates non-coded amino acids and a fatty diacid side chain attached through a linker. This type of lipidation promotes reversible binding to serum albumin and is a well-characterised strategy in peptide chemistry for extending half-life in experimental systems.
In the laboratory it is typically used as a reference compound alongside single- and dual-agonist analogs to compare receptor selectivity, potency and downstream cAMP signaling.
Common research areas
- Multi-receptor agonism in class B GPCR models
- cAMP accumulation and signaling assays
- Structure–activity comparisons with single and dual agonists
- Peptide lipidation and albumin-binding chemistry
Descriptions are general scientific background for laboratory researchers. They are not claims of safety, efficacy or suitability for any use in humans or animals.
| Compound | Retatrutide |
|---|---|
| Description | Synthetic GIP / GLP-1 / glucagon receptor tri-agonist peptide |
| Synonyms | LY3437943 |
| CAS number | 2381089-83-2 |
| Molecular formula | C221H342N46O68 |
| Molecular weight | ≈ 4731.3 g/mol |
| Length | 39 amino acids (lipidated) |
| Available | 10 mg, 20 mg, 30 mg, 40 mg, 50 mg |
| Form | Lyophilized powder, sealed glass vial |
| Purity specification | ≥99% (HPLC) |
| Identity | Mass spectrometry (per lot COA) |
| Lot numbers | CRL-RET-10-0915, CRL-RET-20-0915, CRL-RET-30-0915, CRL-RET-40-0915, CRL-RET-50-0915 |
Reference chemical data is shown for identification. Lot-specific results are reported on the COA.
Store sealed vials refrigerated at 2–8 °C, protected from light and moisture. For extended storage, −20 °C is standard practice for lyophilized peptides. Allow vials to reach room temperature before opening to limit condensation, and avoid repeated freeze–thaw cycles.
Handle all research materials using appropriate laboratory practices and personal protective equipment, in line with your institution’s safety procedures. Keep out of reach of children.
Each container is printed with a lot number (CRL-RET-10-0915, CRL-RET-20-0915, CRL-RET-30-0915, CRL-RET-40-0915, CRL-RET-50-0915). The Certificate of Analysis for each lot reports HPLC purity and mass-spectrometry identity results.
Product information
What is Retatrutide?
A lipidated 39-residue peptide used as a reference tri-agonist in receptor pharmacology studies. It is supplied strictly for laboratory research use.
How is this product supplied?
Lyophilized powder, sealed glass vial. Each container is labeled with its strength and lot number. Strengths available: 10 mg, 20 mg, 30 mg, 40 mg, 50 mg.
Storage & handling
Store sealed vials refrigerated at 2–8 °C, protected from light and moisture. For extended storage, −20 °C is standard practice for lyophilized peptides. Allow vials to reach room temperature before opening to limit condensation, and avoid repeated freeze–thaw cycles.
Shipping
Orders ship after your invoice is paid. Products are packed in protective, discreet packaging, and tracking is emailed when your order ships. See Shipping & Returns for details.
Ordering & payment
Add to cart and submit an order request. We confirm availability and email an invoice with payment instructions. No payment is taken on this website.
COAs & lab reports
Every lot is documented. Use the “Request COA” link above (the lot number is pre-filled) or email support@coastalresearchlabs.com with your lot number.
